Signalling networks for stemness and tumorigenesis

Our gang / Flavio Maina





Group Leader
CNRS CR1
maina@ibdml.univ-mrs.fr





Publication list


21.    A. Moumen, S. Patané, A. Porras, R. Dono and F. Maina. mTOR acts through Mdm2 to signal cell survival in vivo. Development 134:1443-51 (2007)


20.    A. Moumen, A. Ieraci1, S. Patané, C. Solé, J. Comella, R.Dono and F. Maina. Met signals hepatocyte survival by preventing Fas-triggered FLIP degradation in a PI3K/Akt dependent manner. Hepatology 45: 1210-7 (2007)


19.    P. Fazzari, J. Penachioni, S. Gianola, F. Rossi, B.J. Eickholt, F. Maina, L. Alexopoulou, A. Sottile, P.M. Comoglio, R.A. Flavell and L. Tamagnone. Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis. BMC Dev Biol. 7:55-67 (2007)


18.    G. Luxardi, A.Galli, S. Forlani, K. Lawson, F. Maina and R. Dono. Glypicans are differentially expressed during patterning and neurogenesis of early mouse brain. Biochem. Biophys. Res. Commun. 352: 55-60 (2007)


17.    N. Pietrancosta, A. Moumen, R. Dono, P. Lingor, V. Planchamp, F. Lamballe, M. Bähr, J.L. Kraus and F. Maina. Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. J. Med. Chem. 49: 3645-52 (2006)


16.    J. Segarra, L. Balenci, T. Drenth, F. Maina and F. Lamballe. Combined signaling through ERKs, PI3K/Akt and Rac1/p38 is required for Met-triggered cortical neuron migration. J. Biol. Chem. 281: 4771-8 (2006)


15.    G. Pante, J. Thompson, F. Lamballe, T. Iwata, F.A. Barr, A.M. Davies, F. Maina and R. Klein. Mitogen-inducible-gene-6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth. J. Cell Biol. 171: 337-48 (2005)


14.    N. Pietrancosta, F. Maina, R. Dono, A. Moumen, C. Garino, S. Burlet, G. Quéléver and J.L. Kraus. Novel cyclised Pifithrin-a p53 inactivators: synthesis and biological studies. Bioorganic and molecular chemistry letters 15: 1561-4 (2005)


13.    P. Valasek, D.J.R. Evans, F. Maina, M. Grim and K. Patel. A dual fate of the hindlimb muscle mass: cloacal/perineal musculature develops from leg muscle cells. Development 132: 447-58 (2005)


12.    D. Tulasne, J. Deheuninck, F.C. Lourenço, F. Lamballe, Z. Ji, C. Leroy, E. Puchois, A. Moumen, F. Maina, P. Mehlen and V. Fafeur. Proapoptotic function of the MET tyrosine kinase receptor through caspase cleavage. Molecular and Cellular Biology 24(23): 10328-39 (2004)


11.    F. Helmbacher, E. Dessaud, S. Arber, O. deLapeyrière, C. Henderson, R. Klein and F. Maina (2003). Met signaling is required for recruitment of motor neurons to Pea3-positive motor pools. Neuron 39, 767-77 (2003)


10.    F. Maina, G. Pante’, F. Helmbacher, A. Renvaktar, R. Andres, A.M. Davies, C. Ponzetto, and R. Klein. Coupling Met to specific pathways results in distinct developmental outcomes. Molecular Cell 7, 1293-306 (2001)


9.    Caton, A. Hacker, A. Naeem, J. Livet, F. Maina, F. Bladt, R. Klein, C. Birchmeier, and S. Guthrie. The branchial arches and HGF are growth-promoting and chemoattractant for cranial motor axons. Development 127, 1751-60 (2000)


8.     L. Kos, A. Aronzon, H. Takayama, F. Maina, C. Ponzetto, G. Merlino, and W. Pavan. Essential role for c-met in neural-crest derived melanocyte development. Pigment Cell Res 12, 13-21 (1999)


7.    F. Maina, M.C. Hilton, R. Andres, S. Wyatt, R. Klein, and A.M. Davies. Multiple roles for Hepatocyte Growth Factor in sympathetic neuron development. Neuron 20, 835-46 (1998)


6.    F. Maina, M.C. Hilton, C. Ponzetto, A.M. Davies, and R. Klein. Hepatocyte Growth Factor/Met receptor signaling promote axonal growth and survival of sensory neurons. Genes & Development 24, 3341-50 (1997)


5.    F. Maina, F. Casagranda, E. Audero, A. Simeone, P.M. Comoglio, R. Klein, and C. Ponzetto. Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development. Cell 87, 531-42 (1996)


4.     C. Ponzetto, Z. Zhen, E. Audero, F. Maina, A. Bardelli, M.L. Basile, S. Giordano, R. Narsimhan, and P.M. Comoglio. Specific uncoupling of Grb2 from the Met receptor: differential effects on transformation and motility. J. Biol. Chem. 271, 14119-23 (1996)


3.   C. Ponzetto, A. Bardelli, Z. Zhen, F. Maina, P. dalla Zonca, S. Giordano, A. Graziani, G. Panayotou, and P.M. Comoglio. A multifunctional docking site mediates signaling and transformation by the Hepatocyte growth Factor/Scatter Factor (HGF/SF) receptor family. Cell 77, 261-71 (1994)


2.     C. Ponzetto, A. Bardelli, F. Maina, P. Longati, G. Panayotou, R. Dhand, M.D. Waterfield,  and P.M. Comoglio (1993). A novel recognition motif for PI 3-Kinase binding mediates its association with the HGF/SF receptor. Molecular and Cellular Biology 13, 4600-8 (1993)


1.    Bardelli, F. Maina, I. Gout, M.J. Fry, M.D. Waterfield, P.M. Comoglio,  and C. Ponzetto. Autophosphorylation promotes complex formation of recombinant Hepatocyte Growth Factor receptor with cytoplasmic effectors containing SH2 domains. Oncogene 7, 1973-8 (1992)


Reviews and Chapters


7.    A. Fico, F. Maina and R. Dono. Fine-tuning of cell signalling by glypicans. Cellular and Molecular Life Science, Dec 18 [Epub ahead of print]


6.     F. Maina and R. Dono. p53 inhibitors as cancer sensitizing agents. in “Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy", book in press


5.    F. Maina. And Met met plexins. The ELSO Gazette 13, 1-4 (2003)


4.     C. Ponzetto, G. Pante’, C. Prunotto, A. Ieraci, and F. Maina. Met signaling mutants as tools for developmental studies. International J. Dev. Biol. 44, 645-53, (2000)


3.     F. Maina and R. Klein. Hepatocyte Growth factor, a versatile signal for developing neurons. Nature Neuroscience 2 (3), 213-7 (1999)


2.    Bardelli, F. Maina, C. Ponzetto, and P.M. Comoglio. Engineering the Hepatocyte Growth Factor receptor to elucidate its structure and function. in "Progress in Biotechnology" vol. 9, L. Alberghina et al eds., Elsevier Science Publishers B.V., pp157-64 (1994)


1.    E. Vigna, L. Naldini, L. Tamagnone, P. Longati, A. Bardelli, F. Maina, C. Ponzetto, and P.M. Comoglio. Hepatocyte Growth Factor and its receptor, the tyrosine kinase encoded by the c-MET proto-oncogene. Cellular and Molecular Biology 40, 597-604 (1994)



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last updated 13/10/2017